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Seroconversion to measles, diphtheria, tetanus, and pertussis vaccinations in the prophylaxis (CH+) and no prophylaxis (CH-) groups |
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| Vaccine |
Proportion With Seroconversion or Seroresponse (%)† |
P-value (Adjusted For Village) |
Relative Risk (95% CI) |
|
|
|
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| CH+ |
CH- |
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|
|
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| Measles |
127/137(93)* |
180/187 (96) |
0.16* |
0.96 (0.91–1.02)* |
| 109/116 (94) |
0.36 |
0.98 (0.92–1.03) |
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| Diphtheria |
108/147(73)* |
116/135 (86) |
0.26* |
0.86 (0.76–0.96)*‡ |
| 38/ 46 (83) |
0.59 |
0.96 (0.83–1.12) |
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| Tetanus |
104/134(77)* |
126/138 (91) |
0.08* |
0.85 (0.77–0.94)*‡ |
| 41/43 (95) |
0.39 |
1.04 (0.96–1.14) |
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| Pertussis |
63/148(43) * |
113/168 (67) |
<0.01* |
0.63 (0.51–0.78)* |
| 17/44 (39) |
<0.01 |
0.57 (0.39–0.85) |
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* top rows include all CH+ children (bottom rows include only those CH+ children who met criteria for strict compliance) † seroconversion is any increase in titer from a negative baseline for measles; seroresponse is a four-fold or greater rise in titer for diphtheria, tetanus, and pertussis ‡ the discordance between the P-value and confidence interval arises because the latter was calculated from a separate analysis which did not adjust for the random effect of village | ||||
Rosen et al. Malaria Journal 2005 4:53 doi:10.1186/1475-2875-4-53 |
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