Table 1 |
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|
Associations between dhfr and crt mutations in 126 Ghanaian children with uncomplicated malaria |
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| dhfr mutation |
Prevalence of crt T76 mutation (%) |
Odds ratio (95%CI) of crt T76 being present |
|||
|
|
|||||
| Unadjusted |
P |
Adjusted for CQ in blood* |
P |
||
|
|
|||||
| 51 |
|||||
| absent |
67.9 (38/56) |
1 |
1 |
||
| present |
90.0 (63/70) |
4.3 (1.5–12.5) |
0.002 |
5.0 (1.8–13.8) |
0.002 |
| 59 |
|||||
| absent |
63.6 (28/44) |
1 |
1 |
||
| present |
89.0 (73/82) |
4.6 (1.7–13.0) |
0.0007 |
4.4 (1.7–11.4) |
0.002 |
| 108 |
|||||
| absent |
65.7 (23/35) |
1 |
1 |
||
| present |
85.7 (78/91) |
3.1 (1.2–8.6) |
0.01 |
3.2 (1.2–8.2) |
0.02 |
| triple |
|||||
| absent |
68.7 (46/67) |
1 |
1 |
||
| present |
93.2 (55/59) |
6.3 (1.9–26.6) |
0.0006 |
7.0 (2.2–22.5) |
0.001 |
|
|
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|
dhfr, dihydrofolate reductase gene, crt, chloroquine resistance transporter gene; 95%CI, 95% confidence interval; CQ, chloroquine; *, Potential confounders were tested for in logistic regression models including age, sex, parasite density, dhps alleles, and axillary temperature. Adjusted odds ratios include the presence of chloroquine in blood as the only factor found to be associated (univariate odds ratio, 3.2; 95%CI, 1.2–8.6; P = 0.01). |
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|
Mockenhaupt et al. Malaria Journal 2005 4:42 doi:10.1186/1475-2875-4-42 |
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