Table 3 |
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|
NAD+-utilizing enzymes. Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database, the metabolic function of the enzyme. |
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| Enzyme |
EC number |
PfID |
Peak (HPI) |
Metabolic function |
|
|
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| Pyrroline carboxylate reductase |
1.5.1.2 |
MAL13P1.284 |
18 |
Methionine polyamine metabolism |
| Ferrodoxin reductase-like protein |
1.7.1.4 |
PF07_0085 |
21 |
Nitrogen metabolism |
| Glutamate dehydrogenase |
1.4.1.2 |
PF08_0132 |
20 |
Glutamine metabolism |
| Aminomethyltransferase |
2.1.2.10 |
PF13 0345 |
22 |
Folate biosynthesis |
| L-lactate dehydrogenase |
1.1.1.27 |
PF13 0141 |
22 |
Glycolysis |
| Enoyl-acyl carrier reductase |
1.3.1.9 |
MAL6P 1.275 |
30 |
Fatty acid synthesis |
| 2-oxoglutarate dehydrogenase el component |
1.2.4.2 |
PF08_0045 |
30 |
TCA cycle |
| Lipoamide dehydrogenase, putative |
1.8.1.4 |
PF08_0066 |
28 |
TCA cycle |
| Pyruvate dehydrogenase El component, ?-subunit |
1.2.4.1 |
PF11_0256 |
28 |
Fatty acid synthesis |
| NADH-cytochrome b5 reductase |
1.6.2.2 |
PF13_0353 |
32 |
Electron transport |
| Malate dehydrogenase, putative |
1.1.1.37 |
MAL6P 1.242 |
34 |
Pyruvate metabolism |
| Glycerol-3-phosphate dehydrogenase |
1.1.1.8 |
PF11 0157 PFL0780w |
37 19 |
Glycolysis; Glycerol metabolism |
| GDP-mannose 4,6-dehydratase |
1.1.1.187 |
PF08_0077 |
39 |
Mannose and fructose metabolism |
| Inosine-5 '-monophosphate dehydrogenase |
1.1.1.205 |
PFI1020c |
12 |
Purine metabolism |
| 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) |
1.2.4.4 |
PFE0225w |
32 |
Leucine, isoleucine and valine degradation |
| Nitrate reductase |
1.7.1.1 |
chr13.glm_739 |
32 |
Nitrogen metabolism |
|
|
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|
Bozdech and Ginsburg Malaria Journal 2005 4:17 doi:10.1186/1475-2875-4-17 |
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