Table 2 |
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|
Enzymes of the pentose phosphate pathway and pyridine nucleotide metabolism. Enzymes are grouped into pathways. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB)), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database and the metabolic function of the enzyme. |
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| Pathway |
Enzyme |
EC number |
Pf ID |
Peak (HPI) |
|
|
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| Pentose phosphate pathway |
Glucose-6-phosphate dehydrogenase |
1.1.1.49 |
PF14_0511 |
48 |
| 6-phosphogluconolactonase |
3.1.1.31 |
PF14 0511 |
48 |
|
| 6-phosphogluconate dehydrogenase |
1.1.1.44 |
PF14_0520 |
26 |
|
| Ribulose 5-phosphate 3-epimerase |
5.1.3.1 |
PFL0960w |
29 |
|
| Ribose 5-phosphate isomerase |
5.3.1.6 |
PFE0730c |
21 |
|
| Transketolase |
2.2.1.1 |
MAL6P1.110 |
17 |
|
| Ribose phosphate diphosphokinase |
2.7.6.1 |
PF13 0143 PF13 0157 |
21 21 |
|
| Deoxyribose phosphate aldolase |
4.1.2.4 |
PF10 0210 |
21 |
|
| Phosphoglucomutase |
5.4.2.2 |
PF10 0122 |
21 |
|
|
|
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| Pyridine nucleotide metabolism |
Nicotinamidase |
3.5.1.19 |
chr3.glm 243 |
18, 38 |
| Nicotinatephosphoribosyl transferase |
2.4.2.11 |
chr6.glm_337 |
25 |
|
| Nicotinate-nucleotide adenylyl transferase |
2.7.7.18 |
chr13.glm_329 |
20, 40 |
|
| NAD+ synthetase |
6.3.5.1 |
PFI1310w |
28 |
|
| Pyridine nucleotide transhydrogenase |
1.6.1.1. |
PF14_0508 |
32 |
|
|
|
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| Thiamine metabolism |
Hydroxyethylthiazole kinase |
2.7.1.50 |
PFL1920c |
22 |
| Hydroxymethylpyrimidine kinase/ Phosphomethylpyrimidine kinase |
2.7.149 2.7.4.7 |
PFE1030c |
33 |
|
| Thiamine-phosphate diphosphorylase |
2.5.1.3 |
MAL6P1.285 |
1 |
|
| Thiamine diphosphokinase |
2.7.6.2 |
PFI1195c |
28 |
|
|
|
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|
Bozdech and Ginsburg Malaria Journal 2005 4:17 doi:10.1186/1475-2875-4-17 |
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