Table 1 |
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|
NADP utilizing enzymes Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database and the metabolic function of the enzyme. |
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| Enzyme |
EC number |
PfID |
Peak (HPI) |
Metabolic function |
|
|
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| 3-oxoacy1-[acy1-carrier-protein] reductase |
1.1.1.100 |
PFI1125c |
28 |
Fatty acid synthesis |
| 1-deoxy-D-xylulose-5-phosphate reductoisomerase |
1.1.1.267 |
PF14_0641 |
30 |
Isoprenoid metabolism |
| Isocitrate dehydrogenase (NADP+); |
1.1.1.42 |
PF13_0242 |
28 |
TCA cycle |
| Phosphogluconate dehydrogenase |
1.1.1.44 |
PF14_0520 |
26 |
PPP |
| Glucose-6-phosphate 1-dehydrogenase; |
1.1.1.49 |
PF14_0511 |
48 |
PPP |
| Pyruvate dehydrogenase (acetyltransferring). |
1.2.4.1 |
PF11 0256 PF14 0441 |
28 28 |
Pyruvate metabolism |
| Glutamate dehydrogenase (NADP) |
1.4.1.4 |
PF14 0164 PF14 0286 |
1 30 |
Glutamate metabolism |
| Pyrroline-5-carboxylate reductase |
1.5.1.2 |
MAL13P1.284 |
18 |
Proline metabolism |
| Dihydrofolate reductase |
1.5.1.3 |
PFD0830w |
26 |
Folate synthesis |
| NAD(P)+ transhydrogenase (B-specific); |
1.6.1.1 |
PF14_0508 |
32 |
? |
| NADPH hemoprotein reductase |
1.6.2.4 |
PFI1140w |
13 |
Flavoprotein reduction |
| Dihydrolipoamide dehydrogenase |
1.8.1.4 |
PF08 0066 PFL1550w |
28 11 |
Pyruvate metabolism |
| Dihydrolipoamide S-acetyltransferase; |
2.3.1.12 |
PF10 0407 |
28 |
Pyruvate metabolism |
|
|
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|
Bozdech and Ginsburg Malaria Journal 2005 4:17 doi:10.1186/1475-2875-4-17 |
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