Articles
Volume 3 (2004) - July 2004
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Research
Jean-Marc O Depinay, Charles M Mbogo, Gerry Killeen, Bart Knols, John Beier, John Carlson, Jonathan Dushoff, Peter Billingsley, Henry Mwambi, John Githure, Abdoulaye M Toure, F Ellis McKenzie Malaria Journal 2004, 3:29 (30 July 2004) A process-driven model of malaria transmission which allows a better understanding of the mechanisms underlying Anopheles population dynamics.
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Research
Jonathan A Chappel, William O Rogers, Stephen L Hoffman, Angray S Kang Malaria Journal 2004, 3:28 (29 July 2004) The authors have made use of a valuable resource and used the lymphocytes of a volunteer who was immunized with irradiated sporozoites, to create a phage display library of single chain antibodies.
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Research
Care-seeking patterns for fatal malaria in Tanzania Don de Savigny, Charles Mayombana, Eleuther Mwageni, Honorati Masanja, Abdulatif Minhaj, Yahya Mkilindi, Conrad Mbuya, Harun Kasale, Graham Reid Malaria Journal 2004, 3:27 (28 July 2004) This careful analysis of malaria deaths in an area of perennial malarial transmission addresses important issues, showing for instance that the care-seeking behaviour was substantially different in the case of severe malaria and uncomplicated malarial episodes. The limitations of using verbal autopsies are well discussed.
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Research
John PA Lusingu, Lasse S Vestergaard, Bruno P Mmbando, Chris J Drakeley, Caroline Jones, Juma Akida, Zacharia X Savaeli, Andrew Y Kitua, Martha M Lemnge, Thor G Theander Malaria Journal 2004, 3:26 (28 July 2004) How does the burden of malaria morbidity vary with the intensity of transmission.
This is a carefully conducted study in an important but very complex field of medical
research, in which the authors attempt to identify the important aetiological factors and distinguish them from confounding- and effect modifying-factors. It confirms that, in an area of high transmission, young children carry a very high burden of malarial anaemia.
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Research
Tents pre-treated with insecticide for malaria control in refugee camps: an entomological evaluation Kate Graham, Hameed Rehman, Mushtaq Ahmad, Mohammed Kamal, Irfanullah Khan, Mark Rowland Malaria Journal 2004, 3:25 (15 July 2004) Strong canvas polethylene tents pre-treated with insecticides are a useful contribution to malaria control in refugee camps, where other control measures are not practicable.
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Review
Gametocytogenesis : the puberty of Arthur M Talman, Olivier Domarle, F McKenzie, Frédéric Ariey, Vincent Robert Malaria Journal 2004, 3:24 (14 July 2004) A review which addresses several aspects of gametocyte biology, focusing on sex differentiation and determination, transmission strategies and evolution; it highlight areas where the gametocyte might be targetted for control interventions.
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Research
Antioxidant defense in Zbynek Bozdech, Hagai Ginsburg Malaria Journal 2004, 3:23 (9 July 2004) Mining the genome of the malaria parasite in terms of the relative transcription of the various genes of a given biochemical pathway at different stages of the erythrocytic cycle, enables the authors to link the transcriptome data with what is already known of the antioxydant machinery of the parasite. A first step in establishing a gene-function relationship.
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Research
Vincent Corbel, Fabrice Chandre, Cécile Brengues, Martin Akogbéto, Frédéric Lardeux, Jean Hougard, Pierre Guillet Malaria Journal 2004, 3:22 (8 July 2004) The manuscript describes the effect of varying concentrations of permethrin on bed nets
on the behaviour of Anopheles gambiae mosquitoes. It concludes that permethrin-treated nets are unlikely to select for resistance in areas where the kdr allele is heterozygous.
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Research
Ayman Khattab, Christina Reinhardt, Trine Staalsoe, Nadine Fievet, Peter G Kremsner, Philippe Deloron, Lars Hviid, Mo-Quen Klinkert Malaria Journal 2004, 3:21 (8 July 2004) Pregnancy-associated malaria is caused by the sequestration of infected erythrocytes in the placenta, which leads to the selection of pregnancy-specific phenotypes of parasites. The immune response to these phenotypes leads to a special form of pregnancy-specific immunity, which is reinforced in subsequent pregnancies, thus explaining why primiparous women in a malaria-endemic area suffer more from malaria than multigravida.
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Research
Marta Moreno, Jorge Cano, Sisinio Nzambo, Leonardo Bobuakasi, Jesús N Buatiche, Melchor Ondo, Francisco Micha, Agustín Benito Malaria Journal 2004, 3:20 (6 July 2004) Molecular entomological techniques as applied to the study of the vectorial capacity of anophelines in an area of high malarial transmission.
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