|
Enzymes and proteins involved in redox metabolism and their gene/locus in the P. falciparum genome. |
|||
| Process |
Enzyme/protein |
EC number |
Gene/locus |
|
|
|||
| ROS generation |
Fe-superoxide dismutase (possibly an Mn enzyme) |
1.15.1.1 |
PF08_0071 MAL6P1.194 |
| Glutathione biosynthesis and reccycling |
Glutamate-cysteine ligase |
6.3.2.2 |
PFI0925w |
| Glutathione synthase |
6.3.2.3 |
PFE0605c |
|
| Gluathione reductase |
1.8.1.7 |
PF14_0192 |
|
| Glutathione-S-transferase |
2.5.1.18 |
PF14_0187 |
|
| MRP |
PFA0590w PFL1410c |
||
| Glutathione utilization |
Glutathione-S-transferase |
2.5.1.18 |
PF14_0187 |
| 1-Cys peroxiredoxin |
PF08_0131 |
||
| Glutaredoxin |
PFC0271c |
||
| Glutaerdoxin-like protein |
MAL6P1.72 |
||
| Glutaerdoxin-like protein |
PFC0205c |
||
| Lactoylglutathione lyase (glyoxalase I) |
4.4.1.5 |
PF11_0145 |
|
| Hydoxyacylglutathione hydrolase (glyoxalase II) |
3.1.2.6 |
chr4.gen_37 PFL0285w; |
|
| Thioredoxin synthesis and recycling |
Thioredoxin |
MAL13P1.225 |
|
| PF14_0545 |
|||
| PFI0790w |
|||
| PFI1250w |
|||
| Plasmoredoxin |
PFC0165w |
||
| Thioredoxin reductase |
1.8.1.9 |
PFI1170c |
|
| Thioredoxin utilization |
Peroxiredoxin |
MAL7P1.159 |
|
| Trx peroxidase (TPxP) is a |
PF14_0368, 2-cys |
||
| 2-Cys peroxiredoxin |
PFL0725w; 2-cys |
||
| Glutathione peroxidase |
1.11.1.9 |
PFL0595c |
|
| Ribonucleotide reductase, small chain |
1.17.4.1 |
PF10_0154 |
|
| PF14_0053 |
|||
| Oxidative protein folding |
Protein-disulfde isomerase |
5.3.4.1 |
PF11_0352 |
| PF14_0694 |
|||
| MAL8P1.17 |
|||
| PFI0950w |
|||
| PF13_0272 |
|||
| Oxidoreductin (Ero1p) |
PF11_0251 |
||
Bozdech and Ginsburg Malaria Journal 2004 3:23 doi:10.1186/1475-2875-3-23 |
|||