Articles
Volume 2 (2003) - September 2003
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Research
Allan Saul Malaria Journal 2003, 2:32 (19 September 2003) The paper provides a valuable framework for better understanding the concept of zooprophylaxis, the diversion of insects away from humans to animals, and its practical application in control interventions. A teaching model accompanies this article.
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Research
David C Warhurst Malaria Journal 2003, 2:31 (19 September 2003) The hypothesis that PfCRT is an ion channel located in the parasite food vacuole membrane is used here to rationalize the concept of drug resistance. Chloroquine accumulates in the acidic digestive vacuole and prevents the detoxication of haem released during haemoglobin digestion. Mutation of PfCRT in resistant parasites allow the efflux of chloroquine from the vacuole and, thus, result in loss of drug activity.
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Research
Rajinder Kumar, Alla Musiyenko, Sailen Barik Malaria Journal 2003, 2:30 (15 September 2003) Hsp90 appears to be expressed at all stages of development in malaria parasites and the paper shows that the anticancer drug geldanamycin is equally effective against all stages of chloroquine-resistant and chloroquine-sensitive parasites, and that the two agents act synergistically.
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Ernst-Jan Scholte, Basilio N Njiru, Renate C Smallegange, Willem Takken, Bart GJ Knols Malaria Journal 2003, 2:29 (15 September 2003) Since entomophagic fungi affect the survival of adult mosquitoes, they could conceivably represent a method for the biological control of the adult stage, if it was possible to apply encouraging laboratory results, such as reported in this paper, to field conditions.
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Research
Caroline A Maxwell, William Chambo, Mathew Mwaimu, Frank Magogo, Ilona A Carneiro, Christopher F Curtis Malaria Journal 2003, 2:28 (10 September 2003) The study addresses two very important questions. One relates to the value of using treated nets in areas of intense transmission and the other to the possibility that children protected by nets in early life will pay for this with increased morbidity and mortality later on in childhood. On each of these points the data provide encouragement to those who wish to see treated nets used more widely in areas of stable malaria.
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Research
Thomas Lavstsen, Ali Salanti, Anja TR Jensen, David E Arnot, Thor G Theander Malaria Journal 2003, 2:27 (10 September 2003) The authors have used a number of alignment criteria to produce an overview of var genes that will act as a useful basis for further studies, particularly once more sequences from other isolates become available.
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Research
David C Warhurst, John C Craig, Ipemida S Adagu, David J Meyer, Sylvia Y Lee Malaria Journal 2003, 2:26 (1 September 2003) The cinchona alkaloids are the longest standing antimalarial drugs in clinical use, but their mode of action is still incompletely understood. This is the first study to provide comprehensive physico-chemical information regarding these alkaloids.The results strikingly demonstrate that the antimalarially inactive threo compounds are all considerably more hydrophilic than the active erythro compounds and that they are also very weak inhibitors of beta-haematin formation in contrast to the strongly active erythro compounds that inhibit beta-haematin formation better.
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