Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker
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* Corresponding author: Tomas Jelinek jelinek@bbges.de
Malaria Journal 2003, 2:5 doi:10.1186/1475-2875-2-5
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Colin J Sutherland, Matt Laundy, Nicholas Price, Martina Burke, Quinton L Fivelman, Geoffrey Pasvol, John L Klein, Peter L Chiodini Malaria Journal 2008, 7:240 (20 November 2008) New evidence on role of mutations in malaria parasite cytochrome gene in cases of atovaquone resistance
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Rommanee Khositnithikul, Peerapan Tan-ariya, Mathirut Mungthin Malaria Journal 2008, 7:23 (28 January 2008) The absence of cross-resistance between atovaquone and most available drugs in 83 isolates suggests that AP could be used as an alternative antimalarial drug in Thailand.
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Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites Marie-Thérèse Ekala, Nimol Khim, Eric Legrand, Milijaona Randrianarivelojosia, Ronan Jambou, Thierry Fandeur, Didier Menard, Serge-Brice Assi, Marie-Claire Henry, Christophe Rogier, Christiane Bouchier, Odile Mercereau-Puijalon Malaria Journal 2007, 6:164 (17 December 2007) A study of sequence variation of Plasmodium falciparum cytochrome b from various locations on three continents discussing possible relevance to clinical failure
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Mirjam Schönfeld, Isabel Barreto Miranda, Mirjam Schunk, Ibrahim Maduhu, Leonard Maboko, Michael Hoelscher, Nicole Berens-Riha, Andrew Kitua, Thomas Löscher Malaria Journal 2007, 6:2 (15 January 2007) The confirmation of a high prevalence of mutations conferring SP resistance correspond to data of in vivo SP efficacy studies in other regions of Tanzania and underline the need for changing first-line treatment to artemisinin-based combination therapy
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Tamirat Gebru, Asrat Hailu, Peter G Kremsner, Jürgen FJ Kun, Martin P Grobusch Malaria Journal 2006, 5:112 (21 November 2006) In the absence of drug pressure, spontaneous and possibly resistance-conferring mutations are rare. Only 10% mutant types were found in Gabonese isolates and all isolates from Ethiopia were wild-type.
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Christian T Happi, Grace O Gbotosho, Onikepe A Folarin, Danny Milner, Ousmane Sarr, Akintunde Sowunmi, Dennis E Kyle, Wilbur K Milhous, Dyann F Wirth, Ayoade MJ Oduola Malaria Journal 2006, 5:82 (4 October 2006) Report on the frequence of mutations associated with atovaquone resistance in Plasmodium falciparum isolates from three African countries.
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Sónia Pimentel, Fátima Nogueira, Carla Benchimol, Vatúsia Quinhentos, Joana Bom, Luís Varandas, Virgílio do Rosário, Luís Bernardino Malaria Journal 2006, 5:30 (5 April 2006) No mutation of the cytochrome b gene has been detected in this study, suggesting that for time being atovaquone-proguanil can continue to be recommended for travellers to Angola.
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