Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa
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* Corresponding author: Alexis Nzila anzila@wtnairobi.mimcom.net
Malaria Journal 2003, 2:46 doi:10.1186/1475-2875-2-46
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Chloroquine resistance before and after its withdrawal in Kenya Leah Mwai, Edwin Ochong, Abdi Abdirahman, Steven M Kiara, Steve Ward, Gilbert Kokwaro, Philip Sasi, Kevin Marsh, Steffen Borrmann, Margaret Mackinnon, Alexis Nzila Malaria Journal 2009, 8:106 (18 May 2009) Description of a longitudinal study of the prevalence of alleles of P. falciparum that associated with resistance to chloroquine and pyrimethamine in Kilifi, Kenya between 1993 and 2006. This data set was used to calculate the selection coefficient and infer the apparent fitness of the different alleles. This is a salutary reminder that the control of anti-malarial drug use is loose in most settings and the impact of official changes in policy is complex and unpredictable.
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