Malaria Journal

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Epidemiological models for the spread of anti-malarial resistance

JC Koella* and R Antia

Malaria Journal 2003, 2:3 doi:10.1186/1475-2875-2-3

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BioMed Central: 5 citations

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Mathematical models of malaria - a review

Sandip Mandal, Ram Sarkar, Somdatta Sinha Malaria Journal 2011, 10:202 (21 July 2011)

A timely review article that aims to assess the current state of the malaria modelling field, predominantly focusing on mathematical (rather than statistical) models.

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Spread of anti-malarial drug resistance: Mathematical model with implications for ACT drug policies

Wirichada Pongtavornpinyo, Shunmay Yeung, Ian M Hastings, Arjen M Dondorp, Nicholas PJ Day, Nicholas J White Malaria Journal 2008, 7:229 (2 November 2008)

This article describes a new simulation model for malaria. It is, quite obviously, not the first model of its type, but it is an exceptional example of a simulation model. The model is complex enough to give some confidence in the epidemiological significance.

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Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population

Sonja Schoepflin, Jutta Marfurt, Mary Goroti, Moses Baisor, Ivo Mueller, Ingrid Felger Malaria Journal 2008, 7:78 (6 May 2008)

An original and interesting approach where the hypothesis that drug resistant malaria parasites are at a fitness disadvantage compared to susceptible parasites is tested by analysing mutations of parasite genes associated with drug resistance

Research   Open Access

Clinically immune hosts as a refuge for drug-sensitive malaria parasites

Eili Y Klein, David L Smith, Maciej F Boni, Ramanan Laxminarayan Malaria Journal 2008, 7:67 (25 April 2008)

The authors describe a novel malaria transmission model system that accounts for clinical immunity. The model generates outcomes consistent with the empirical (and seemingly paradoxical) observation of slow onset of resistance in high transmission settings.

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Modelling the impact of intermittent preventive treatment for malaria on selection pressure for drug resistance

Neal Alexander, Colin Sutherland, Cally Roper, Badara Cissé, David Schellenberg Malaria Journal 2007, 6:9 (22 January 2007)

The paper adds more quantitation to the debate on how intermittent preventive treatmentof infants (IPTi) will affect parasite resistance patterns in different epidemiologic settings. The model suggests that IPTi will add little to the selective pressure if it is delivered only to infants, as in Tanzania, but may add substantially to this pressure if delivered to a wider age range, as would be the case in the seasonal IPTi scenario proposed for Senegal.