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Molecular surveillance of the antifolate-resistant mutation I164L in imported african isolates of Plasmodium falciparum in Europe: sentinel data from TropNetEurop

Ole Wichmann*†, Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Martin P Grobusch, Joaquim Gascon, Alberto Matteelli, Christoph Hatz, Hermann Laferl, Marco Schulze, Gerd Burchard, Saraiva da Cunha, Jiøi Beran, Paul McWhinney, Herwig Kollaritsch, Peter Kern, Juan Cuadros, Michael Alifrangis, Ida Gjørup and the European Network on Surveillance of Imported Infectious Diseases (TropNetEurop)

Malaria Journal 2003, 2:17 doi:10.1186/1475-2875-2-17

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Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa

Edwin Ochong, Alexis Nzila, Serah Kimani, Gilbert Kokwaro, Theonest Mutabingwa, William Watkins, Kevin Marsh Malaria Journal 2003, 2:46 (15 December 2003)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

This study confirms that mutation Leu-164 is not currently found in this recent sample of viable Tanzanian parasites: this finding is important, especially with the introduction of LapDap which will increase the selective advantage of the Leu-164 mutation. Continuous monitoring will be required in Africa.

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