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Open Access Highly Accessed Research

Rapid case-based mapping of seasonal malaria transmission risk for strategic elimination planning in Swaziland

Justin M Cohen1*, Sabelo Dlamini2, Joseph M Novotny13, Deepika Kandula13, Simon Kunene2 and Andrew J Tatem45

Author Affiliations

1 Clinton Health Access Initiative, Boston, MA, USA

2 National Malaria Control Programme, Mbabane, Swaziland

3 Global Health Group, University of California, San Francisco, USA

4 Department of Geography and Environment, University of Southampton, Southampton, UK

5 Fogarty International Center, NIH, Bethesda, MD, USA

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Malaria Journal 2013, 12:61  doi:10.1186/1475-2875-12-61

Published: 11 February 2013

Abstract

Background

As successful malaria control programmes move towards elimination, they must identify residual transmission foci, target vector control to high-risk areas, focus on both asymptomatic and symptomatic infections, and manage importation risk. High spatial and temporal resolution maps of malaria risk can support all of these activities, but commonly available malaria maps are based on parasite rate, a poor metric for measuring malaria at extremely low prevalence. New approaches are required to provide case-based risk maps to countries seeking to identify remaining hotspots of transmission while managing the risk of transmission from imported cases.

Methods

Household locations and travel histories of confirmed malaria patients during 2011 were recorded through routine surveillance by the Swaziland National Malaria Control Programme for the higher transmission months of January to April and the lower transmission months of May to December. Household locations for patients with no travel history to endemic areas were compared against a random set of background points sampled proportionate to population density with respect to a set of variables related to environment, population density, vector control, and distance to the locations of identified imported cases. Comparisons were made separately for the high and low transmission seasons. The Random Forests regression tree classification approach was used to generate maps predicting the probability of a locally acquired case at 100 m resolution across Swaziland for each season.

Results

Results indicated that case households during the high transmission season tended to be located in areas of lower elevation, closer to bodies of water, in more sparsely populated areas, with lower rainfall and warmer temperatures, and closer to imported cases than random background points (all pā€‰<ā€‰0.001). Similar differences were evident during the low transmission season. Maps from the fit models suggested better predictive ability during the high season. Both models proved useful at predicting the locations of local cases identified in 2012.

Conclusions

The high-resolution mapping approaches described here can help elimination programmes understand the epidemiology of a disappearing disease. Generating case-based risk maps at high spatial and temporal resolution will allow control programmes to direct interventions proactively according to evidence-based measures of risk and ensure that the impact of limited resources is maximized to achieve and maintain malaria elimination.