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This article is part of the supplement: Challenges in malaria research

Open Access Poster presentation

Insecticide-treated durable wall lining for malaria control: multicentre studies from Africa and South-East Asia

Louisa A Messenger1*, Abrahan Matias Arnez2, JB Stiles-Ocran3, Mamadou B Coulibaly4, Marie-Louise Larsen5, Nathan Miller6, Adedapo O Adeogun7, CEG Mulder8, Hoan Le9, Immo Kleinschmidt1 and Mark Rowland1

  • * Corresponding author: Louisa A Messenger

Author Affiliations

1 Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK

2 Medical Care Development International (MCDI), Malabo, Equatorial Guinea

3 Entomology Research Unit, Malaria Control Centre, AngloGold Ashanti Ltd., Obuasi, Ghana

4 Vector Genomics and Proteomics, Malaria Research and Training Centre (MRTC), University of Sciences, Techniques and Technologies, Bamako, Mali

5 Technical Institute of Denmark (DTU), Lyngby Denmark

6 The MENTOR Initiative, Huambo, Angola

7 Molecular Entomology and Vector Control Research Laboratory, Nigerian Institute of Medical Research, Lagos, Nigeria

8 Agricultural Research Station (Pty) Ltd., Friedenhiem JT 282, Nelspruit, South Africa

9 Vestergaard Frandsen Laboratories, 253/9 Minh Khai, Hai Ba Trung district, Hanoi, Vietnam

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Malaria Journal 2012, 11(Suppl 1):P121  doi:10.1186/1475-2875-11-S1-P121

The electronic version of this article is the complete one and can be found online at: http://www.malariajournal.com/content/11/S1/P121


Published:15 October 2012

© 2012 Messenger et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Indoor residual spraying (IRS) is a primary method of malaria vector control but its potential impact is constrained by several inherent limitations: spraying must be repeated when insecticide residues decay, householders may object to the annual imposition and campaign costs are recurrent. Durable wall lining (DL) can be considered a novel form of long-lasting IRS, which gradually releases insecticide over a period of three to four years when used to cover interior house walls. DL is designed to overcome the logistical constraints associated with repeated rounds of spraying whilst retaining the most attractive feature of IRS, the protection of all members of the community [1-3]. To establish DL as a viable substitute it must demonstrate equivalent or superior levels of bioefficacy, acceptability, durability and logistical feasibility to currently available products.

Materials and methods

To identify a desirable material to develop into a durable wall lining, a one year preliminary trial was conducted among rural and urban households in Angola and Nigeria (n=258) comparing three deltamethrin-treated prototype materials (polyethylene shade cloth, laminated polyethylene sheeting and mosquito wall netting) [4]. The most popular lining material (shade cloth polyethylene, henceforth DL) was then evaluated in comparison with conventional IRS during a one year multicentre trial conducted in rural households in malaria endemic Equatorial Guinea, Ghana, Mali, South Africa and Vietnam (n=220).

Results

During the preliminary trial a dichotomy between rural and urban participants emerged. Rural households favoured wall adornments and accepted wall linings because of their perceived decorative value and entomological efficacy, whereas urban households preferred minimal wall decoration and objected to the materials aesthetics and installation feasibility. Of the prototype lining materials assessed, polyethylene shade cloth DL was the most popular because of its ease of installation, aesthetics and resemblance to locally available materials. During the multicentre field trial, DL demonstrated consistently higher levels of bioefficacy compared to IRS, with no significant loss of bioactivity after 12 months. Field samples of DL retained on average 78% of their original insecticide content after one year. The majority of households reported reductions in mosquito density (93%) and biting (82%), but no adverse changes to their indoor environment (83%). When offered a choice of vector control product at the end of trial, the majority of participants chose DL regardless of the earlier household allocation.

Conclusions

These two trials represent the largest field evaluation of DL to date [4]. The high level of acceptability among rural inhabitants identifies these communities as the ideal target consumer group for DL. DL remained fully efficacious against mosquito vectors, demonstrated minimal loss of insecticide content over 12 months of field use and was unequivocally more popular than IRS and other long-lasting vector control products. Together these results demonstrate that DL has the potential to overcome many of the operational challenges associated with IRS and may represent a viable long-lasting alternative, a scenario not dissimilar to the advantages and superiority shown by long-lasting insecticidal nets when introduced in place of conventional insecticide-treated nets.

References

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    Am J Trop Med Hyg 2012, 87:242-250. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

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  4. Messenger LA, Miller NR, Adeogun AO, Awolola TS, Rowland M: The development of insecticide-treated durable wall lining for malaria control: insights from rural and urban populations in Angola and Nigeria.

    Malaria J 2012.

    Accepted

    OpenURL