Table 4

Association of different phenotypes of P.falciparum placental malaria with mutations MBL2*G57E and MASP2*R439H

MBL2*G57E (MBL2*C; rs1800451)

MASP2*R439H (rs12085877)


Wildtype (GG)

Mutation (AA or AG)

p-value

OR

Wildtype (CC)

Mutation (TT or TC)

p-value

OR


Placental malaria

45.5% (56/123)

60.7% (88/145)

0.014

1.84 (1.13-3.01)

57.7% (113/196)

43.8% (32/73)

0.054

0.58 (0.33-0.99)


Maternal peripheral blood


PCR positive

53.7% (66/123)

63.4% (92/145)

0.108

1.50 (0.92-2.45)

62.2% (122/196)

49.3% (36/73)

0.070

0.59 (0.34-1.02)


Microscopy positive

24.8% (29/117)

29.0% (40/138)

0.482

28.9% (55/190)

22.7% (15/66)

0.423


Placental blood


PCR positive

60.2% (74/123)

70.3% (102/145)

0.094

1.57 (0.94-2.61)

68.4% (134/196)

58.9% (43/173)

0.151


Microscopy positive

39.0% (48/123)

54.5% (79/145)

0.014

1.86 (1.15-3.05)

49.0% (96/196)

41.1% (30/73)

0.218


Haemozin pigments present

36.9% (45/122)

48.3% (70/145)

0.064

1.59 (0.98-2.62)

48.0% (94/196)

29.2% (21/72)

0.008

0.47 (0.26-0.83)


Low birth weight

27.0% (33/122)

24.1% (35/145)

0.673

28.6% (56/196)

16.7% (12/72)

0.057

0.51 (0.24-0.99)


Maternal anaemia

35.0% (43/123)

40.7% (59/145)

0.378

38.8% (76/196)

35.6% (26/73)

0.673


Preterm birth

27.0% (33/122)

23.4% (34/145)

0.571

23.5% (46/196)

29.2% (21/72)

0.344


Holmberg et al. Malaria Journal 2012 11:61   doi:10.1186/1475-2875-11-61

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