Table 3

Single marker results of allelic and genotypic association with placental malaria

Allelic associations

Genotypic association


Gene

SNP

Mutation

All. freq cases

All. freq controls

P-value

Permuted P-value

Odds ratio

95% CI

Best genotypic model

Empirical p-value


MBL2

rs1800451

G57E

0.36

0.26

0.014

0.014

1.60

1.10-2.32

Dominant

0.021


MASP2

rs12085877

H439R

0.11

0.19

0.014

0.020

0.55

0.34-0.89

Allelic

0.015


MASP2

rs1033638

3'UTR

0.36

0.27

0.04

0.022

1.52

1.01-2.26

Trend

0.064


FCN2

rs3128624

Intron 2

0.67

0.62

0.198

0.204

1.27

0.88-1.81

Dominant

0.053


FCN2

rs7037264

Intron 3

0.68

0.64

0.271

0.261

1.23

0.85-1.76

Dominant

0.042


CFP

rs909523

Intron 6

0.57

0.47

0.019

0.029

1.51

1.07-2.13

Trend

0.043


Holmberg et al. Malaria Journal 2012 11:61   doi:10.1186/1475-2875-11-61

Open Data