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Efficacy of artemether-lumefantrine as a treatment for uncomplicated Plasmodium vivax malaria in eastern Sudan

Tajeldin M Abdallah1, Abdel Aziem A Ali1, Mohammed Bakri1, Gasim I Gasim13, Imad R Musa14 and Ishag Adam2*

Author Affiliations

1 Faculty of Medicine, Kassala University, Kassala, Sudan

2 Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan

3 Faculty of Medicine, Qassim University, Qassim, Qassim, Kingdom of Saudi Arabia

4 Buraidah Central Hospital, Buraidah, Kingdom of Saudi Arabia

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Malaria Journal 2012, 11:404  doi:10.1186/1475-2875-11-404

Published: 5 December 2012



Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated Plasmodium falciparum malaria in most areas of the world, where malaria is endemic, including Sudan. However, few published data are available on the use of ACT for treatment of P. vivax malaria.


This study was conducted at a health centre in Kassala, eastern Sudan, from October to December 2011. Patients with uncomplicated P. vivax malaria received artemether-lumefantrine (AL) tablets (containing 20mg artemether and 120 mg lumefantrine) and were monitored for 28 days.


Out of the 43 cases enrolled in this study, 38 completed the 28-day follow-up. Their mean age was 25.1 years (SD: 1.5). On day 3 following AL treatment, all of the patients were afebrile and aparasitaemic. By day 28, all 38 patients exhibited adequate clinical and parasitological responses to AL treatment. The cure rate was 100% and 88.4% for the per protocol analysis andfor the intention to treat analysis, respectively. Mild adverse effects (nausea, vomiting, abdominal pain, dizziness and/or rash) that resolved spontaneously were observed in four (10.5%) of the patients.


AL combination therapy was fully effective for treatment of P. vivax malaria in the study in eastern Sudan.

Trial registration

Trial. Gov: NCT01625871

Efficacy; Artemether-lumefantrine; Malaria; P. vivax; Sudan.