Malaria research challenges in low prevalence settings
1 Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, W1CE 7HT, UK
2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA
3 Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, W1CE 7HT, UK
4 Malaria Institute at Macha, Choma, Zambia
5 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA
Malaria Journal 2012, 11:353 doi:10.1186/1475-2875-11-353Published: 25 October 2012
The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.