Email updates

Keep up to date with the latest news and content from Malaria Journal and BioMed Central.

Open Access Highly Accessed Commentary

Malaria research challenges in low prevalence settings

Gillian Stresman1, Tamaki Kobayashi2, Aniset Kamanga3, Philip E Thuma4, Sungano Mharakurwa45, William J Moss2 and Clive Shiff5*

Author Affiliations

1 Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, W1CE 7HT, UK

2 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA

3 Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, W1CE 7HT, UK

4 Malaria Institute at Macha, Choma, Zambia

5 Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA

For all author emails, please log on.

Malaria Journal 2012, 11:353  doi:10.1186/1475-2875-11-353

Published: 25 October 2012

Abstract

The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.