Email updates

Keep up to date with the latest news and content from Malaria Journal and BioMed Central.

Open Access Highly Accessed Case report

The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

Eric Farfour16, Frédéric Charlotte2, Catherine Settegrana5, Makoto Miyara34 and Pierre Buffet178*

Author Affiliations

1 Laboratoire de parasitologie-mycologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651, Paris Cedex 13, France

2 Laboratoire d'anatomie-pathologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

3 Service de médecine interne 2, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

4 Département d’immunologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

5 Laboratoire d’hématologie, Assistance publique hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France

6 Unité Prévention et Thérapie Moléculaire des Maladies Humaines, CNR des corynébactéries du complexe diphtheriae, Institut Pasteur, 25-28 rue du Dr Roux, 75014, Paris, France

7 Unité d'Immunologie Moléculaire des Parasites, Institut Pasteur, Paris, France

8 Inserm-UPMC, Paris 6 Université, UMRs945, 91 boulevard de l’hôpital, 75013, Paris, France

For all author emails, please log on.

Malaria Journal 2012, 11:285  doi:10.1186/1475-2875-11-285

Published: 20 August 2012

Abstract

Background

Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.

Methods

The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.

Results

A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.

Discussion and conclusion

These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.

Keywords:
Malaria; Transmission; Gametocyte; Bone marrow; Plasmodium falciparum