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Open Access Case report

Imported Plasmodium falciparum malaria in HIV-infected patients: a report of two cases

Silvia García-Bujalance1*, Carolina Navarro-San Francisco2, José M Rubio3, José R Arribas4 and Avelino Gutierrez1

Author Affiliations

1 Department of Microbiology and Parasitology, La Paz University Hospital-IdiPAZ, Paseo de la Castellana 261, 28046 Madrid, Spain

2 Infectious Diseases and Clinical Microbiology Unit, Division of Internal Medicine and Division of Microbiology, La Paz University Hospital-IdiPAZ, Paseo de la Castellana 261, 28046 Madrid, Spain

3 Malaria and Emerging Parasitic Diseases Laboratory, Parasitology Department, Nacional Centre of Microbilogy, Instituto de Salud Carlos III, Cra. Majadahonda Pozuelo Km 2, Majadahonda, 28220 Madrid, Spain

4 HIV Unit and Infectious Diseases and Clinical Microbiology Unit, Division of Internal Medicine and Division of Microbiology, La Paz University Hospital-IdiPAZ, Paseo de la Castellana 261, 28046 Madrid, Spain

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Malaria Journal 2012, 11:136  doi:10.1186/1475-2875-11-136

Published: 27 April 2012

Abstract

As HIV becomes a chronic infection, an increasing number of HIV-infected patients are travelling to malaria-endemic areas. Association of malaria with HIV/AIDS can be clinically severe. Severe falciparum malaria is a medical emergency that is associated with a high mortality, even when treated in an Intensive Care Unit. This article describes two cases of HIV-positive patients, who returned from malaria-endemic areas and presented a parasitaemia > 5% of erythrocytes and clinical signs of severe falciparum malaria, both with > 350 CD4 cell count/μl, absence of chemoprophylaxis and successful response. Factors like drug interactions and the possible implication of anti-malarial therapy bioavailability are all especially interesting in HIV-malaria co-infections.

Keywords:
Plasmodium falciparum; HIV; Imported malaria; Sequence analysis; Drug interaction