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Open Access Highly Accessed Methodology

The parasite clearance curve

NJ White

Author Affiliations

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Centre for Tropical Medicine, Churchill Hospital, Oxford University, Oxford, UK

Malaria Journal 2011, 10:278  doi:10.1186/1475-2875-10-278

Published: 22 September 2011

Abstract

Parasite clearance rates are important measures of anti-malarial drug efficacy. They are particularly important in the assessment of artemisinin resistance. The slope of the log-linear segment in the middle of the parasite clearance curve has the least inter-individual variance and is the focus of therapeutic assessment. The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed.