Table 3 |
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|
Bilayer ASAQ tablet formulation for high dosage and low dosage ASAQ tablets |
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|
Composition |
Content (%w/w) |
Quantity (mg/tablet) |
|
|
|
|||
|
Layer 1 (blend no 30154C01 ) |
high dosage tablet (batch 30154C03) |
low dosage tablet (batch 30154C04) |
|
|
|
|||
|
Dry granulated AQH |
50.38 |
352.64 |
88.16 |
|
|
|||
|
Sodium Croscarmellose (AcDiSol) |
1.40 |
9.80 |
2.45 |
|
|
|||
|
Polyvinylpyrrolidone (PVP K30) |
1.14 |
8.00 |
2.00 |
|
|
|||
|
Magnesium stearate |
1.32 |
9.26 |
2.315 |
|
|
|||
|
Silicon dioxide (Aerosil 300) |
0.11 |
0.75 |
0.1875 |
|
|
|||
|
Ca carbonate |
7.71 |
54.00 |
13.50 |
|
|
|||
|
Total layer 1 |
62.06 |
434.45 |
108.61 |
|
|
|||
|
Layer 2 (blend 30154C03) |
|||
|
|
|||
|
AS |
14.29 |
100.00 |
25.00 |
|
|
|||
|
Polyvinylpyrrolidone (PVP K30) |
1.14 |
8.00 |
2.00 |
|
|
|||
|
Sodium Croscarmellose (AcDiSol) |
1.40 |
9.80 |
2.45 |
|
|
|||
|
Magnesium stearate |
0.43 |
3.00 |
0.75 |
|
|
|||
|
Silicon dioxide (Aerosil 300) |
0.11 |
0.75 |
0.1875 |
|
|
|||
|
Calcium carbonate |
7.71 |
54.00 |
13.50 |
|
|
|||
|
Microcrystalline cellulose |
12.86 |
90.00 |
22.50 |
|
|
|||
|
Total layer 2 |
37.94 |
265.55 |
66.39 |
|
|
|||
|
Total |
100.00 |
700.00 |
175.00 |
|
|
|||
|
Lacaze et al. Malaria Journal 2011 10:142 doi:10.1186/1475-2875-10-142 |
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