Table 7 |
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|
Number of isolates clustered according to sensitivity to each drug and corresponding pfcrt and pfmdr1 genotypes |
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|
Drug |
Pfcrt |
Pfmdr1 |
|||||||||||
|
76K |
76T |
76KT |
86N |
86Y |
86NY |
1042N |
1042D |
1042ND |
1246D |
1246Y |
1246DY |
||
|
|
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|
CQ |
Total |
||||||||||||
|
S |
2 |
2 |
0 |
0 |
1 |
1 |
0 |
2 |
0 |
0 |
2 |
0 |
0 |
|
R |
50 |
0 |
43 |
7 |
30 |
11 |
9 |
43 |
4 |
0 |
46 |
1 |
3 |
|
MF |
|||||||||||||
|
S |
35 |
2 |
27 |
6 |
2 |
11 |
7 |
29 |
3 |
0 |
32 |
1 |
2 |
|
R |
17 |
0 |
16 |
1 |
29 |
1 |
2 |
16 |
1 |
0 |
16 |
0 |
1 |
|
QUIN |
|||||||||||||
|
S |
52 |
2 |
43 |
7 |
31 |
12 |
9 |
45 |
4 |
0 |
48 |
1 |
3 |
|
R |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
AMQ |
|||||||||||||
|
S |
13 |
0 |
9 |
4 |
9 |
2 |
2 |
13 |
0 |
0 |
12 |
0 |
1 |
|
R |
18 |
2 |
13 |
3 |
7 |
4 |
7 |
15 |
0 |
0 |
15 |
1 |
2 |
|
|
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|
(CQ – chloroquine; MF – mefloquine; QUIN – quinine; AMQ – amodiaquine; S – sensitive; R – resistant; 76KT, 86NY, 1042ND and 1246DY – mixed infections; shaded boxes indicate the two cases where there was a significant association between the presence of a particular marker and drug sensitivity: pfcrt 76T/CQR, P = 0.001 and pfmdr1 86N/MFR, P < 0.001) |
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|
Lopes et al. Malaria Journal 2002 1:12 doi:10.1186/1475-2875-1-12 |
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