Table 2 |
||||
|
Total distribution of resistance-associated mutations and wild type among imported isolates of P. falciparum in Europe |
||||
| Resistance to |
Gene locus |
Mutation (%) |
Wild type (%) |
Total |
|
|
||||
| Chloroquine |
Pfcrt 76 |
204 (68.2%) |
95 (31.8%) |
299 |
| Pfmdr 86 |
85 (42.3%) |
116 (57.7%) |
201 |
|
| Group I antifolates |
DHFR 51 |
135 (44.3%) |
170 (55.7%) |
305 |
| DHFR 108 |
170 (58.4%) |
121 (41.6%) |
291 |
|
| DHFR 59 |
156 (55.1%) |
127 (44.9%) |
283 |
|
| Group II antifolates |
DHPS 436 |
79 (33.3%) |
158 (66.7%) |
237 |
| DHPS 437 |
92 (40.4%) |
136 (59.6%) |
228 |
|
| DHPS 540 |
12 (5.3%) |
216 (94.7%) |
228 |
|
| DHPS 581 |
6 (2.3%) |
255 (97.7%) |
261 |
|
|
|
||||
|
Group I antifolates: e.g. pyrimethamine. Group II antifolates: sulfonamides DHFR = dihydrofolate reductase DHPS = dihydropteroate synthetase |
||||
|
Jelinek et al. Malaria Journal 2002 1:11 doi:10.1186/1475-2875-1-11 |
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