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In vitro sensitivity of isolate NGATV01 and strain K1 to standard antimalarial drugs with standard deviations (nmol/L). |
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| Drug |
NGATV01 |
K1 |
Resistance Cut-off* |
|
|
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| Mean IC50 ± SD |
Mean IC50 ± SD |
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|
|
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| Chloroquine |
9.54 ± 1.18 |
133.29 ± 30.12 |
100 |
| Mefloquine |
24.14 ± 5.20 |
8.55 ± 0.29 |
20 |
| Pyrimethamine |
16012.80 ± 2643.55 |
8082.84 ± 1202.69 |
100 |
| Atovaquone |
1888.15 ± 106.65 |
2.41 ± 1.01 |
20 |
| Proguanil |
4205.50 ± 716.99 |
10239.94 ± 843.51 |
not determined |
| Dihydroartemisinin |
2.39 ± 0.07 |
1.26 ± 0.46 |
not determined |
|
Drug assay was performed at 1 % parasitaemia and 1 % haematocrit. Experiment was repeated twice in duplicate.* Cut-off points for resistance as previously reported [16,17,6] | |||
Fivelman et al. Malaria Journal 2002 1:1 doi:10.1186/1475-2875-1-1 |
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