Table 1

In vitro sensitivity of isolate NGATV01 and strain K1 to standard antimalarial drugs with standard deviations (nmol/L).

Drug
NGATV01
K1
Resistance Cut-off*




Mean IC50 ± SD
Mean IC50 ± SD


Chloroquine
9.54 ± 1.18
133.29 ± 30.12
100
Mefloquine
24.14 ± 5.20
8.55 ± 0.29
20
Pyrimethamine
16012.80 ± 2643.55
8082.84 ± 1202.69
100
Atovaquone
1888.15 ± 106.65
2.41 ± 1.01
20
Proguanil
4205.50 ± 716.99
10239.94 ± 843.51
not determined
Dihydroartemisinin
2.39 ± 0.07
1.26 ± 0.46
not determined

Drug assay was performed at 1 % parasitaemia and 1 % haematocrit. Experiment was repeated twice in duplicate.* Cut-off points for resistance as previously reported [16,17,6]

Fivelman et al. Malaria Journal 2002 1:1   doi:10.1186/1475-2875-1-1