References

  1. Llanos-Cuentas A, Campos P, Clendenes M, Canfield CJ, Hutchinson DB: Atovaquone and proguanil hydrochloride compared with chloroquine or pyrimethamine/sulfadoxine for treatment of acute Plasmodium falciparum malaria in Peru.

    Braz J Infect Dis 2001, 5:67-72. PubMed Abstract OpenURL

  2. Looareesuwan S, Chulay JD, Canfield CJ, Hutchinson DB: Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group.

    Am J Trop Med Hyg 1999, 60:533-541. PubMed Abstract OpenURL

  3. Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, et al.: Atovaquone-Proguanil versus Mefloquine for Malaria Prophylaxis in Nonimmune Travellers: Results from a Randomized, Double-Blind Study.

    Clin Infect Dis 2001, 33:1015-1021. PubMed Abstract | Publisher Full Text OpenURL

  4. Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, et al.: Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team.

    Lancet 2000, 356:1888-1894. PubMed Abstract | Publisher Full Text OpenURL

  5. Desjardins R, Canfield C, Haynes J, Chulay J: Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

    Antimicrob Agents Chemother 1979, 16:710-718. PubMed Abstract OpenURL

  6. Korsinczky M, Chen N, Kotecka B, Saul A, Rieckmann K, Cheng Q: Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site.

    Antimicrob Agents Chemother 2000, 44:2100-2108. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  7. Fry M, Pudney M: Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80).

    Biochem Pharmacol 1992, 43:1545-1553. PubMed Abstract | Publisher Full Text OpenURL

  8. Srivastava IK, Rottenberg H, Vaidya AB: Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite.

    J Biol Chem 1997, 272:3961-3966. PubMed Abstract | Publisher Full Text OpenURL

  9. Looareesuwan S, Viravan C, Webster HK, Kyle DE, Hutchinson DB, Canfield CJ: Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.

    Am J Trop Med Hyg 1996, 54:62-66. PubMed Abstract OpenURL

  10. Vaidya AB, Mather MW: Atovaquone resistance in malaria parasites.

    Drug Resist Updat 2000, 3:283-287. PubMed Abstract | Publisher Full Text OpenURL

  11. Shretta R, Brugha R, Robb A, Snow RW: Sustainability, affordability, and equity of corporate drug donations: the case of Malarone.

    Lancet 2000, 355:1718-1720. PubMed Abstract | Publisher Full Text OpenURL

  12. Butcher GA, Mendoza J, Sinden RE: Inhibition of the mosquito transmission of Plasmodium berghei by Malarone (atovaquone-proguanil).

    Ann Trop Med Parasitol 2000, 94:429-436. PubMed Abstract OpenURL

  13. Srivastava IK, Morrisey JM, Darrouzet E, Daldal F, Vaidya AB: Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.

    Mol Microbiol 1999, 33:704-711. PubMed Abstract | Publisher Full Text OpenURL

  14. Crofts AR, Hong S, Ugulava N, Barquera B, Gennis R, Guergova-Kuras M, et al.: Pathways for proton release during ubihydroquinone oxidation by the bc(1) complex.

    Proc Natl Acad Sci U S A 1999, 96:10021-10026. PubMed Abstract | Publisher Full Text | PubMed Central Full Text OpenURL

  15. Guex N, Diemand A, Peitsch MC: Protein modelling for all.

    Trends Biochem Sci 1999, 24:364-367. PubMed Abstract | Publisher Full Text OpenURL

  16. Gay F, Bustos D, Traore B, Jardinel C, Southammavong M, Ciceron L, et al.: In vitro response of Plasmodium falciparum to atovaquone and correlation with other antimalarials: comparison between African and Asian strains.

    Am J Trop Med Hyg 1997, 56:315-317. PubMed Abstract OpenURL

  17. Basco LK, Ramiliarisoa O, Le Bras J: In vitro activity of pyrimethamine, cycloguanil, and other antimalarial drugs against African isolates and clones of Plasmodium falciparum.

    Am J Trop Med Hyg 1994, 50:193-199. PubMed Abstract OpenURL