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The magnitude and trend of artemether-lumefantrine stock-outs at public health facilities in Kenya
Raymond K Sudoi, Sophie Githinji, Andrew Nyandigisi, Alex Muturi, Robert W Snow, Dejan Zurovac Malaria Journal 2012, 11:37 (8 February 2012)
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Editor’s summary
A paper which helps to understand how supply is organized from central to peripheral level, and how this might affect the supply of peripheral units.
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Human Plasmodium knowlesi infection in Ranong province, southwestern border of Thailand
Natthawan Sermwittayawong, Balbir Singh, Mitsuaki Nishibuchi, Nongyao Sawangjaroen, Varaporn Vuddhakul Malaria Journal 2012, 11:36 (8 February 2012)
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Plasmodium knowlesi infection in humans along the southwestern border of Thailand, including interesting discussion on the possible changes in epidemiology.
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Human cerebral malaria and Plasmodium falciparum genotypes in Malawi
Danny A Milner, Jimmy Vareta, Clarissa Valim, Jacqui Montgomery, Rachel F Daniels, Sarah K Volkman, Daniel E Neafsey, Daniel J Park, Stephen F Schaffner, Nira C Mahesh, Kayla G Barnes, David M Rosen, Amanda K Lukens, Daria Van Tyne, Roger C Wiegand, Pardis C Sabeti, Karl B Seydel, Simon J Glover, Steve Kamiza, Malcolm E Molyneux, Terrie E Taylor, Dyann F Wirth Malaria Journal 2012, 11:35 (7 February 2012)
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An interesting study confirming that the parasite genetic complexity is lower in cerebral malaria than in patients with non-complicated malaria. In their study, the authors found that cerebral malaria patients harbour a parasite population dominated by a single variant identical throughout the blood and organs.
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Anti-malarial drugs: how effective are they against Plasmodium falciparum gametocytes?
Christopher L Peatey, Didier Leroy, Donald L Gardiner, Katharine R Trenholme Malaria Journal 2012, 11:34 (6 February 2012)
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Cytoadherence and virulence - the case of Plasmodium knowlesi malaria
Farrah A Fatih, Angela Siner, Atique Ahmed, Lu Chan Woon, Alister G Craig, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh Malaria Journal 2012, 11:33 (3 February 2012)
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Editor’s summary
Another twist in the tale of cytoadherence ? Is in vitro cytoadherence really a marker of virulence, even in case of parasites, such as P. knowlesi or P. vivax, which are not normally sequestered ?
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Can universal insecticide-treated net campaigns achieve equity in coverage and use? The case of northern Nigeria
Yazoume Ye, Elizabeth Patton, Albert Kilian, Samantha Dovey, Erin Eckert Malaria Journal 2012, 11:32 (1 February 2012)
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Using data from a post-campaign survey, the authors investigated the effect of the mass distribution campaigns in achieving equity in household ownership and use ITNs
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Attractive toxic sugar bait (ATSB) methods decimate populations of Anopheles malaria vectors in arid environments regardless of the local availability of favoured sugar-source blossoms
John C Beier, Gunter C Muller, Weidong Gu, Kristopher L Arheart, Yosef Schlein Malaria Journal 2012, 11:31 (1 February 2012)
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Editor’s summary
This field study in the arid malaria-free oasis environment of Israel compares how the availability of a primary natural sugar source for mosquitoes - flowering Acacia trees - affects the efficacy of ATSB methods for mosquito control.
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Apoptosis of the fibrocytes type 1 in the spiral ligament and blood labyrinth barrier disturbance cause hearing impairment in murine cerebral malaria
Joachim Schmutzhard, Christian H Kositz, Rudolf Glueckert, Erich Schmutzhard, Annelies Schrott-Fischer, Peter Lackner Malaria Journal 2012, 11:30 (1 February 2012)
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Editor’s summary
The paper describes histopathological changes induced by a murine malaria infection and relates this with hearing loss. It uses a well-stablished experimental model and addresses a major issue for malaria patients.
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The complexities of malaria disease manifestations with a focus on asymptomatic malaria
Dolie D Laishram, Patrick L Sutton, Nutan Nanda, Vijay L Sharma, Ranbir C Sobti, Jane M Carlton, Hema Joshi Malaria Journal 2012, 11:29 (31 January 2012)
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Editor’s summary
The pathogenesis of malaria is complex, and the clinical presentation of disease ranges from severe malaria, to mild and uncomplicated, to asymptomatic infections. Asymptomatic malaria remains a major challenge for malaria control programmes.
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Strengthening the policy setting process for global malaria control and elimination
Bianca J D'Souza, Robert D Newman Malaria Journal 2012, 11:28 (27 January 2012)
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Editor’s summary
A new Thematic Series in Malaria Journal will, after each meeting of the Malaria Policy Advisory Committee (MPAC), a new WHO committee, publish its recommendations and the evidence to support them.
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Visual and olfactory associative learning in the malaria vector Anopheles gambiae sensu stricto
Nora Chilaka, Elisabeth Perkins, Frederic Tripet Malaria Journal 2012, 11:27 (27 January 2012)
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The paper investigated associative learning in Anopheles
gambiae in a laboratory bioassay using visual and olfactory cues. The results address an important knowledge gap in mosquito ecology and emphasize the role of associative memory for host finding and blood-feeding behaviour, with important potential implications for vector control.
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Hyponatraemia in imported malaria: the pathophysiological role of vasopressin
Ewout J Hoorn, Marlies E van Wolfswinkel, Dennis A Hesselink, Yolanda B de Rijke, Rob Koelewijn, Jaap J van Hellemond, Perry JJ van Genderen Malaria Journal 2012, 11:26 (26 January 2012)
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Editor’s summary
This is a retrospective study of 519 cases of imported malaria, examining patterns and mechanisms of associated hyponatraemia. The results, which builds on work by the same authors published last year, is timely, because the issue of fluid resuscitation of patients with malaria controversial.
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Comparing changes in haematologic parameters occurring in patients included in randomized controlled trials of artesunate-amodiaquine vs single and combination treatments of uncomplicated falciparum in sub-Saharan Africa
Julien Zwang, Jean-Louis Ndiaye, Abdoulaye Djimde, Grant Dorsey, Andreas Martensson, Corine Karema, Piero Olliaro Malaria Journal 2012, 11:25 (25 January 2012)
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Effect of different antimalarial treatments on haematologic parameters comparing artesunate-amodiaquine against various single treatment lines and combination therapies.
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Aging partially restores the efficacy of malaria vector control in insecticide-resistant populations of Anopheles gambiae s.l. from Burkina Faso
Christopher M Jones, Antoine Sanou, Wamdaogo M Guelbeogo, N'Fale Sagnon, Paul C D Johnson, Hilary Ranson Malaria Journal 2012, 11:24 (23 January 2012)
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Editor’s summary
The main finding here is that older mosquitoes are more susceptible to insecticides. This has important implications for understanding the epidemiological impact of resistance in field-based vector control interventions.
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Development of a TaqMan Allelic Discrimination Assay for detection of Single Nucleotides Polymorphisms associated with anti-malarial drug resistance
Edwin Kamau, Saba Alemayehu, Karla C Feghali, LaDonna S Tolbert, Bernard Ogutu, Christian F Ockenhouse Malaria Journal 2012, 11:23 (20 January 2012)
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Editor’s summary
Paper reporting the development of a TaqMan Real Time PCR assay for the detection of SNPs associated with anti-malarial resistance. This assay has promise as a convenient and efficient way to examine patient samples in resource-constrained settings.
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Plate-based transfection and culturing technique for genetic manipulation of Plasmodium falciparum
Florence Caro, Mathew G. Miller, Joseph L. DeRisi Malaria Journal 2012, 11:22 (18 January 2012)
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Editor’s summary
Paper describing a series of semi-automated protocols that will facilitate transfection of P. falciparum.
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Integrated vector management for malaria control in Uganda: knowledge, perceptions and policy development
Clifford M Mutero, Dieter Schlodder, Narcis Kabatereine, Randall Kramer Malaria Journal 2012, 11:21 (14 January 2012)
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Editor’s summary
This paper focuses on status of Integrated Vector Management in Uganda and is a good demonstration how surveys of individuals in different sectors can advance the development of IVM-based programmes in African countries.
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Importance of factors determining the effective lifetime of a mass, long-lasting, insecticidal net distribution: a sensitivity analysis
Olivier JT Briƫt, Diggory Hardy, Thomas A Smith Malaria Journal 2012, 11:20 (13 January 2012)
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Editor’s summary
Use of a pre-existing agent-based mathematical modelling platform for malaria to extend knowledge that is based on field studies on net and insecticide decay to model and estimate the epidemiological lifetimes of insecticide-treated bed nets under field conditions. A topic about which rather little is actually known.
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Changes in malaria morbidity and mortality in Mpumalanga Province, South Africa (2001-2009): a retrospective study
Lindokuhle Ngomane, Christiaan de Jager Malaria Journal 2012, 11:19 (13 January 2012)
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Editor’s summary
This paper provides an interesting descriptive review of nine years (eight malaria seasons) of routine malaria data from Mpumalanga Province, South Africa.
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Distance to health services influences insecticide-treated net possession and use among six to 59 month-old children in Malawi
Peter S Larson, Don P Mathanga, Carl H Campbell, Mark L Wilson Malaria Journal 2012, 11:18 (11 January 2012)
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Editor’s summary
The authors analysed the significance of distance and ITN possession/use through standard statistical tests. Strategies that exclusively distribute ITNs through health facilities are likely to be less effective in increasing possession and use in communities that are more distant from those facilities.
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Target product profiles for protecting against outdoor malaria transmission
Gerry F Killeen, Sarah J Moore Malaria Journal 2012, 11:17 (11 January 2012)
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Editor’s summary
The authors extend a previously published mathematical model to investigate the combined use of outdoor and indoor malaria vector control tools. These tools consist of a contact toxicant and a spatial repellent.
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Mutant pfcrt "SVMNT" haplotype and wild type pfmdr1 "N86" are endemic in Plasmodium vivax dominated areas of India under high chloroquine exposure
Prashant K Mallick, Hema Joshi, Neena Valecha, Surya K Sharma, Alex Eapen, Rajendra M Bhatt, Harish C Srivastava, Patrick L Sutton, Aditya P Dash, Virendra K Bhasin Malaria Journal 2012, 11:16 (11 January 2012)
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Editor’s summary
In this study, the distribution of pfcrt haplotypes and the pfmdr-1 mutation (N86Y) has been described across 11 sites in India and evaluated for a correlation between the prevalence of mutations and the clinical outcome of CQ treatment.
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The evil circle of poverty: a qualitative study of malaria and disability
Benedicte Ingstad, Alister C Munthali, Stine H Braathen, Lisbet Grut Malaria Journal 2012, 11:15 (11 January 2012)
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Editor’s summary
This study points to the importance of building malaria programmes, research and statistics that take into consideration the consequences of permanent impairment after a malaria attack, as well as the context of poverty in which they often occur.
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Understanding the population genetics of Plasmodium vivax is essential for malaria control and elimination
Alicia Arnott, Alyssa E Barry, John C Reeder Malaria Journal 2012, 11:14 (10 January 2012)
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Editor’s summary
With malaria elimination back on the global agenda, mapping of global and local P. vivax population structure is essential prior to establishing goals for elimination and the roll-out of interventions.
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Atorvastatin treatment is effective when used in combination with mefloquine in an experimental cerebral malaria murine model
Jean Baptiste Souraud, Sebastien Briolant, Jerome Dormoi, Joel Mosnier, Helene Savini, Eric Baret, Remy Amalvict, Raoulin Soulard, Christophe Rogier, Bruno Pradines Malaria Journal 2012, 11:13 (10 January 2012)
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Editor’s summary
The paper addresses the potential of statins in preventing experimental cerebral.
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